臧敬五

臧敬五 - 简介

主要成果：
臧敬五教授的研究是立足于从临床问题中提炼出关键免疫学科学问题，用最新的科学手段在分子和细胞水平上进行研究，并致力于成果的临床应用。
一、通过对髓鞘抗原自身反应T细胞的研究，揭示了其在体内激活的可能机理及在多发性硬化炎症和中枢神经系统脱髓鞘病理过程中的关键作用。
二、首创用灭活髓鞘抗原反应T细胞治疗多发性硬化(T细胞疫苗)。初步阐明了其体内免疫调节机理，并正在探索T细胞疫苗在多发性硬化和类风湿关节炎免疫治疗中的临床应用前景，研制T细胞受体多肽治疗性疫苗。

臧敬五 - 主要论文、著作

近三年代表性论文：

JingwuZhang.YinandYanginterplayofIFN-gammaininflammationandautoimmunedisease.JournalofClinicalInvestigation2007,inpress

GuangjieChen,NingliLi,YingC.Q.Zang,DongqingZhang,DongyiHe,GuozhangFeng,LiqingNi,RongXu,LiWang,BaihuaShen,JingwuZhang.VaccinationWithSelectedSynovialTCellsinRheumatoidArthritis.ArthritisandRheumatism56(2),453-463,2007.
*ThispaperisaccompaniedwithanEditorialpublishedinthesameissue:
BrentPrakkenandSalvatoireAlbani.ExploitingTcellcrosstalkasavaccinationstrategyforrheumatoidarthritis.ArthritisandRheumatism56,389-392,2007

ZhaojunWang,JianHong,WeiSun,GuangwuXu,NingliLi,XiChen,AilianLiu,LingyunXu,BingSun,JingwuZhang.Roleofg-InterferoninInductionofFoxp3andConversionofCD4+CD25-TcellstoCD4+RegulatoryTCells.JournalofClinicalInvestigation.2006Sep1;116(9):2434-2441.

BingWan,HongNie,AilianLiu,GuozhangFeng,DongyiHe,RongXu,QiZhang,ChenDong,JingwuZhang.AberrantRegulationofSynovialTCellActivationbySolubleCo-StimulatoryMoleculesinRheumatoidArthritis.JournalofImmunology177(12):8844-8850,2006.

GuilinYang,AilianLiu,QingXie,TaylorB.Guo,BingWan,BopingZhou,JingwuZhang.AssociationofCD4+CD25+Foxp3+RegulatoryTCellswithChronicActivityandViralClearanceinPatientswithHepatitisB.InternationalImmunology.2006Dec20;[Epubaheadofprint]

JianHong,YingZang,HongNieandJingwuZhang.CD4+RegulatoryTCellresponsesinducedbyTcellvaccinationinpatientswithmultiplesclerosis.ProceedingsofNationalAcademyofScienceUSA103:5024-5029,2006

GuangwuXu,HongNie,NingliLi,WenxinZheng,DongqingZhang,GuozhangFeng,LiqingNi,RongXu,JianHong,JingwuZhang.Roleofosteopontininamplificationandperpetuationofrheumatoidsynovitis.JournalofClinicalInvestigation115(4):1060-1067,2005

JianHong,NingliLi,XuejunZhang,BiaoZheng,JingwuZhang.InductionofExpressionofTranscriptionFactorFoxP3andFunctionofCD4+CD25+RegulatoryTCells.ProceedingsofNationalAcademyofScienceUSA102(18):6449-6454,2005

GuangwuXu,WeiSun,DongyiHe,LiWang,WenxinZheng,HongNie,LiqingNi,DongqingZhang,NingliLi,JingwuZhang.Overexpressionofosteopontininrheumatoidsynovialmononuclearcellsisassociatedwithjointinflammation,notwithgeneticpolymorphism.JournalofRheumatology32:410-416,2005

WeiSun,HongNie,NingliLi,YingZang,DongqingZhang,GuozhangFeng,LiqingNi,RongXu,SarvamangalaPrasad,RachelRRobinson,WalterHo,EliSercarz,JingwuZhang.SkewedT-cellreceptorBV14andBV16expressionandsharedCDR3sequenceandcommonsequencemotifsinsynovialTcellsofrheumatoidarthritis.GenesandImmunity6:248-261,2005

臧敬五 - 参考资料